Precision Neuropsychiatry through nmda
Critical Target for Neuropsychiatry
NMDAR is an ionotropic channel which, upon activation, let calcium enter the cell, controlling neuronal plasticity, the 1st step of memory processing
NMDAR overactivation participates to the physiopathology of major neuropsychiatric diseases such as PTSD, Depression, Alzheimer’s, Parkinson’s, ALS, Huntington’s
Only channel blockers have successfully reached the market (Amantadine for PD, Memantine for AD, Dextromethorphan for Depression, and Ketamine for MDD) despite decades of scientific research targeting the extracellular domain (selective antagonists, reverse agonists, allosteric modulators)
Their lack of selectivity and specificity results in moderate performance and unwanted side effects
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Our Molecular Platform and Innovative Approach Translates into a Diverse Pipeline
RST-101
Early Treatment for PTSD
RST-01 is a novel and proprietary chemical entity specifically targeting certain NMDA receptor subtypes involved in synaptic plasticity. It facilitates stress extinction and neuroprotection without triggering the adverse side effects classically encountered with less selective NMDA targeting drugs. RST-01 restores the memorization process when taken following a traumatic event.
RST-101: Mechanism of Action
Specifically Inhibits NMDAR GluN2D Subunit
Interneuron Mediated Function Disrupted Following Trauma
Overactivated pyramidal neurons result in the excitotoxicity and reduced plasticity
Activated inhibitory interneurons prevent normal memory formation.
Pyramidal Function Restoration, through RST-101 Interneuron Engagement
RST-01 Specifically targets NMDA receptors subtype GluN2D on inhibitory interneurons associated with learnings and memory formation
Enables memory rebalancing while preventing side effects due to the absence of NMDAR GluN2A & GluN2B inhibition of pyramidal neurons
ReST Therapeutics
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